Major depression

is one of the most common mental disorders in the United States.

  • An estimated 21.0 million adults in the United States had at least one major depressive episode in the past year
  • This number represents 8.3% of all U.S. adults
  • The standard of care for depression is treatment with antidepressant medications
  • In some cases, depression symptoms do not improve with antidepressant treatment
  • Continued symptoms of depression after trying at least two separate antidepressant medications may indicate Treatment Resistant Depression (TRD)

SPRAVATO® (Esketamine) Antidepressant Treatment

Spravato NWN 8
  • Indicated for treatment resistant depression (TRD) in adults
  • Prescription, FDA-approved nasal spray
  • Made up of the chemical esketamine
  • Administered in a healthcare clinic intranasally
  • Used in conjunction with an oral antidepressant
  • Spravato® can provide relief from treatment resistant major depression within hours of using it
  • Typically includes giving yourself 3 doses of the nasal spray
  • Spaced 5-minutes apart
  • Administered under medical supervision
  • Administered in a medical clinic
  • Treatment session lasts approximately two hours
  • Note: Due to possible side effects patients must have a ride home (family member, friend, car service)
  • Treatments are often covered by health insurance
  • Out of pocket cost determined prior to treatment
  • Visit Spravato’s website to learn about financial support options
  • Sleepiness, fainting, dizziness, or a spinning sensation
  • Anxiety, or feeling disconnected from yourself, your thoughts and feelings, and from space and time
  • Must have a diagnosis of Treatment Resistant Depression (TRD)
  • Must be taking at least one oral antidepressant medication
  • Must be engaged with a therapist, in either Cognitive Behavioral Therapy (CBT) or Dialectical Behavioral Therapy (DBT)
  • SPRAVATO® is not approved for patients with bipolar disorder or schizophrenia
  • Must have a referral
  • Children
  • Pregnant or plan to become pregnant
  • History of substance abuse
  • Blood vessel disease or a history of bleeding in the brain
  • Uncontrolled hypertension
What to Expect

A patient-friendly video overview of the SPRAVATO® treatment process.

Ask the Experts

Doctors answer patients’ top 9 questions about SPRAVATO®. Be sure to watch the full video to get the full SPRAVATO® story, including safety information.

Nicole’s Story

SPRAVATO® helped Nicole’s treatment-resistant depression. Now, she’s resuming her education and sharing her story.

Allison’s Story

Allison’s son tried many oral antidepressants without relief. Now, because of SPRAVATO®, Allison’s son is starting to feel like himself again.

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